Nanoscopic Resolution of the Glass Transition within Spatially Inhomogeneous Polymer Mixtures

10.1021/acscentsci.8b00164

2018-04-06

Christie, Register, and Priestley report the first direct measurement of the glass transition temperature as a function of location within a bulk nanostructured polymer material.

Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

10.1021/acscentsci.8b00098

2018-04-05

Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and oligonucleotides. Although hundreds of CPP sequences are described in the literature, predicting efficacious sequenc...

Elegant Approach to the Controllability of the Mechanical Properties of a Microgel via the Self-Assembly of Internal Molecules

10.1021/acscentsci.8b00167

2018-04-05

Gelatin microgels synthesized inside droplets and stabilized by lipid membranes could move the field of protein-like polymer microgels.

Mapping Catalytically Relevant Edge Electronic States of MoS2

10.1021/acscentsci.8b00042

2018-04-03

Molybdenum disulfide (MoS2) is a semiconducting transition metal dichalcogenide that is known to be a catalyst for both the hydrogen evolution reaction (HER) as well as for hydro-desulfurization (HDS) of sulfur-rich hydrocarbon fuels. Specifically, the edges ...

Detecting the Sweet Biomarker on Cancer Cells

10.1021/acscentsci.8b00156

2018-03-29

A sugar molecule expressed on cancer cells can be chemoenzymatically labeled for fluorescent imaging and proteomic analysis.

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides

10.1021/acscentsci.7b00581

2018-03-28

Peptide display has enabled identification and optimization of ligands to many targets. These ligands are usually linear or disulfide-containing peptides that are vulnerable to proteolysis or reduction. We report yeast surface and phage display of lanthipepti...

Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics

10.1021/acscentsci.7b00612

2018-03-28

The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyrosine resid...

Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy

10.1021/acscentsci.8b00035

2018-03-28

Cancer vaccine aims to invoke antitumor adaptive immune responses to detect and eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have several limitations that are mostly derived from the ex vivo culture of patient DCs. To cir...

Stable Metal–Organic Frameworks with Group 4 Metals: Current Status and Trends

10.1021/acscentsci.8b00073

2018-03-26

Group 4 metal-based metal–organic frameworks (MIV-MOFs), including Ti-, Zr-, and Hf-based MOFs, are one of the most attractive classes of MOF materials owing to their superior chemical stability and structural tunability. Despite being a relatively new field,...

Looking at the Disordered Proteins through the Computational Microscope

10.1021/acscentsci.7b00626

2018-03-22

Intrinsically disordered proteins (IDPs) have attracted wide interest over the past decade due to their surprising prevalence in the proteome and versatile roles in cell physiology and pathology. A large selection of IDPs has been identified as potential targ...