阿齐沙坦酯钾盐

• 常用名: 阿齐沙坦酯钾盐
• 英文名: azilsartan kamedoxomil
• CAS号: 863031-24-7
• 分子量: 606.62
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₂₃KN₄O₈
• 熔点: N/A
• 闪点: N/A

阿齐沙坦酯钾盐用途

Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂，IC50为0.62 nM。

阿齐沙坦酯钾盐名称

• 中文名: 阿齐沙坦酯钾盐
• 英文名: azilsartan kamedoxomil

阿齐沙坦酯钾盐生物活性

• 描述: Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.

  [2]. Kusumoto K, Igata H, Ojima M, Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models.

  [3]. Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39.

  [4]. Pierini D, Anderson KV. Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013 May;47(5):694-703.

阿齐沙坦酯钾盐物理化学性质

• 分子式: C₃₀H₂₃KN₄O₈
• 分子量: 606.62
• PSA: 155.59000
• LogP: 4.70520
• 储存条件: 2-8℃

阿齐沙坦酯钾盐英文别名

• UNII-WEC6I2K1FC
• TAK-491
• Azilsartan medoxomil monopotassium
• WEC6I2K1FC
• azilsartan kamedoxomil
• Potassium 3-{4'-[(2-ethoxy-7-{[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl}-1H-benzimidazol-1-yl)methyl]-2-biphenylyl}-5-oxo-1,2,4-oxadiazol-4-ide
• potassium,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-1-oxa-2-aza-4-azanidacyclopent-2-en-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• Azilsartan kamedoxomil (USAN)
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt (1:1)
• Azilsartan (medoxomil monopotassium)