苯甲丁氮酮结构式
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常用名 | 苯甲丁氮酮 | 英文名 | Nadolol |
|---|---|---|---|---|
| CAS号 | 42200-33-9 | 分子量 | 309.40100 | |
| 密度 | 1.189g/cm3 | 沸点 | 526.4ºC at 760mmHg | |
| 分子式 | C17H27NO4 | 熔点 | 125-130ºC | |
| MSDS | 美版 | 闪点 | 272.2ºC |
苯甲丁氮酮用途Nadolol (SQ-11725) 是一种非选择性的具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,也是有机阴离子转运多肽 1A2 (OATP1A2) 的一种底物。Nadolol 可用于高血压,心绞痛和血管性头痛的研究。 |
| 中文名 | 苯甲丁氮酮 |
|---|---|
| 英文名 | (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol |
| 中文别名 | 氢萘心安 |
| 英文别名 | 更多 |
| 描述 | Nadolol (SQ-11725) 是一种非选择性的具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,也是有机阴离子转运多肽 1A2 (OATP1A2) 的一种底物。Nadolol 可用于高血压,心绞痛和血管性头痛的研究。 |
|---|---|
| 相关类别 | |
| 体外研究 | 在人胚肾293细胞中,(-)-表没食子儿茶素没食子酸酯(EGCG)竞争性地抑制OATP1A2介导的纳多洛尔摄取,Ki值为19.4μM。相对于纳多洛尔,OATP1A2的Km为84μM[2]。 |
| 体内研究 | 在携带B16F10肿瘤细胞的1只雄性小鼠中,通过给予纳多洛尔(20mg/kg)阻断神经内分泌反应,导致暴露于急性社会压力的受试者的肺转移灶越来越小[3]。 |
| 参考文献 |
| 密度 | 1.189g/cm3 |
|---|---|
| 沸点 | 526.4ºC at 760mmHg |
| 熔点 | 125-130ºC |
| 分子式 | C17H27NO4 |
| 分子量 | 309.40100 |
| 闪点 | 272.2ºC |
| 精确质量 | 309.19400 |
| PSA | 81.95000 |
| LogP | 1.02570 |
| 外观性状 | 白色固体 |
| 折射率 | 1.573 |
| 储存条件 | Refrigerator |
| 水溶解性 | Slightly soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in acetone. |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 2 |
| RTECS号 | QJ4870000 |
| 海关编码 | 2922509090 |
| 海关编码 | 2922509090 |
|---|---|
| 中文概述 | 2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装 |
| 监管条件 | A.入境货物通关单 B.出境货物通关单 |
| 检验检疫 | R.进口食品卫生监督检验 S.出口食品卫生监督检验 |
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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| nadolol |
| 5-[3-(tert-butylamino)-2-oxopropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol |
| [14C]-Nadolol |
| Nadic |
| 5-[3-[(1,1-dimethylethyl)-amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-cis-naphthalenediol |
| Solgol |
| Nadololum |
| Nadololum [INN-Latin] |
| Corgaretic |
| 1-tert.-butylamino-3-(1,2,3,4-tetrahydro-2,3-dihydroxy-5-napthyloxy)-2-propanol |
| Anabet |
| Corgard |
| (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol |
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