结构式 物理化学性质
常用名 咪康唑 英文名 Miconazole
CAS号 22916-47-8 分子量 416.12900
密度 1.4g/cm3 沸点 555.1ºC at 760mmHg
分子式 C18H14Cl4N2O 熔点 159-163ºC
MSDS N/A 闪点 289.5ºC
符号 GHS07
GHS07
信号词 Warning
 产品用途
属咪唑类广谱抗霉菌药。对新生隐球菌、念珠菌、球孢子菌、组织胞浆菌和皮炎牙生菌等抗菌活性好。对毛发癣菌和皮肤癣菌有效,但对由霉菌和部分白色含球菌作用差。  

 物理化学性质
[ 密度 ]: 1.4g/cm3
[ 沸点 ]: 555.1ºC at 760mmHg
[ 熔点 ]: 159-163ºC
[ 分子式 ]: C18H14Cl4N2O
[ 分子量 ]: 416.12900
[ 闪点 ]: 289.5ºC
[ 精确质量 ]: 413.98600
[ PSA ]: 27.05000
[ LogP ]: 6.45480
[ 外观性状 ]: 白色粉末
[ 蒸汽压 ]: 6.07E-13mmHg at 25°C
[ 折射率 ]: 1.639
 MSDS
Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Miconazole
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302:Harmful if swallowed
H317:May cause an allergic skin reaction
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P280:Wear protective gloves/protective clothing/eye protection/face protection
P301+P312:IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P363:Wash contaminated clothing before reuse
P321:Specific treatment (see on this label)

Section3. Composition/information on ingredients.
Ingredient name:Miconazole
CAS number:22916-47-8

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
No data
Boiling point:
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C18H14Cl4N2O
Molecular weight: 416.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A
 毒性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI4770000
CHEMICAL NAME :
Imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)pheneth yl)-
CAS REGISTRY NUMBER :
22916-47-8
BEILSTEIN REFERENCE NO. :
0965511
LAST UPDATED :
199806
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C18-H14-Cl4-N2-O
MOLECULAR WEIGHT :
416.14
WISWESSER LINE NOTATION :
T5N CNJ A1YR BG DG&O1R BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
104 mg/kg/4D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
349 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
519 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90570 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
800 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3100 mg/kg
SEX/DURATION :
female 1-31 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION :
4160 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 79,169,1980 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,333,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4278 No. of Facilities: 46 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8954 (estimated) No. of Female Employees: 7689 (estimated)
 安全信息
[ 符号 ]: GHS07
GHS07
[ 信号词 ]: Warning
[ 危害声明 ]: H302-H413
[ 警示性声明 ]: P301 + P312 + P330
[ 危害码 (欧洲) ]: Xn
[ 风险声明 (欧洲) ]: R22
[ 安全声明 (欧洲) ]: 22-36
[ 危险品运输编码 ]: UN 3249
[ 包装等级 ]: III
[ 危险类别 ]: 6.1(b)
[ 海关编码 ]: 2933290090
 合成线路

~70%

文献: : Cruz-Almanza, Raymundo; Hernandez, Teresa; Perez, Francisco; Lemini, Cristina Organic Preparations and Procedures International, 1992 , vol. 24, # 3 p. 342 - 345

~%

文献: : Organic Preparations and Procedures International, , vol. 24, # 3 p. 342 - 345

~%

文献: : Organic Preparations and Procedures International, , vol. 24, # 3 p. 342 - 345
 海关
[ 海关编码 ]: 2933290090
[ 中文概述 ]: 2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]: 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
 文献58更多
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