2,3'-脱水胸苷结构式
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常用名 | 2,3'-脱水胸苷 | 英文名 | 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)- |
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| CAS号 | 15981-92-7 | 分子量 | 224.21 | |
| 密度 | 1.72g/cm3 | 沸点 | 381.8ºC at 760mmHg | |
| 分子式 | C10H12N2O4 | 熔点 | 246-247ºC | |
| MSDS | 美版 | 闪点 | 184.7ºC |
2,3'-脱水胸苷用途2,3'-无水硫脒；2'-脱氧-3',2-氢-5-甲基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。 |
| 中文名 | 2,3’-脱水胸苷 |
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| 英文名 | 2,3'-anhydrothymidine |
| 中文别名 | 2,3'-脱水胸苷 |
| 英文别名 | 更多 |
| 描述 | 2,3'-无水硫脒；2'-脱氧-3',2-氢-5-甲基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.72g/cm3 |
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| 沸点 | 381.8ºC at 760mmHg |
| 熔点 | 246-247ºC |
| 分子式 | C10H12N2O4 |
| 分子量 | 224.21 |
| 闪点 | 184.7ºC |
| 精确质量 | 208.08500 |
| PSA | 64.35000 |
| 外观性状 | 白色粉末 |
| 蒸汽压 | 2.12E-07mmHg at 25°C |
| 折射率 | 1.735 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
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[3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases].
Bioorg. Khim. 21 , 49-54, (1995) 5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structu... |
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Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.
Nucleosides Nucleotides Nucleic Acids 27 , 1272-1281, (2008) A general method is described for synthesizing 3',5'-dithio-2'-deoxypyrimidine nucleosides 6 and 13 from normal 2'-deoxynucleosides. 2,3'-Anhydronucleosides 2 and 9 are applied as intermediates in the... |
| 2,3'-Anhydro-D-thymidine |
| Anhydrothymidine |
| 2,3'-O-Cyclothymidine |
| 5-methyl-2'-deoxy-2,3'-anhydrouridine |
| threo-2,3'-anhydro-thymidine |
| O2,3'-Cyclothymidine |
