诺拉霉素

更新时间：2024-01-09 20:24:13

诺拉霉素结构式	常用名	诺拉霉素	英文名	Nogalamycin
	CAS号	1404-15-5	分子量	787.80
	密度	1.49g/cm3	沸点	899.9ºC at 760mmHg
	分子式	C₃₉H₄₉NO₁₆	熔点	N/A
	MSDS	中文版美版	闪点	498.1ºC
	符号	GHS07, GHS08	信号词	Danger

诺拉霉素用途

诺加霉素是蒽环素类抗生素。诺加霉素是一种有效的抗革兰氏阳性菌抗生素,对某些肿瘤细胞也有细胞毒性。诺加拉霉素由诺加拉链霉菌诺加拉变种产生。诺加霉素在与DNA模板结合后选择性抑制RNA合成。诺加霉素可用于研究抗癌药物[1][2]。

中文名	诺拉霉素
英文名	nogalamycin
英文别名	更多

描述	诺加霉素是蒽环素类抗生素。诺加霉素是一种有效的抗革兰氏阳性菌抗生素,对某些肿瘤细胞也有细胞毒性。诺加拉霉素由诺加拉链霉菌诺加拉变种产生。诺加霉素在与DNA模板结合后选择性抑制RNA合成。诺加霉素可用于研究抗癌药物[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成信号通路 >> 抗感染 >> 细菌
靶点	RNA Synthesis[2]
体外研究	诺加霉素(0-10μg/ml；2小时)对CHO、L1210和B16具有致死性,LD50分别为2.74μg/ml、0.25μg/ml和0.15μg/ml【1】。细胞毒性试验细胞系：CHO、L1210和B16细胞【1】浓度：0-10μg/ml孵育时间：2小时结果：LD50s分别为2.74μg/ml、0.25μg/ml和0.15μg/ml,对CHO、L1210和B16具有杀伤力。
体内研究	诺加霉素(0-1000μg/kg；IP)可以逆转化学诱导的大鼠纤维肉瘤肿瘤和自发性肿瘤[3]。动物模型：大鼠【1】剂量：0-1000μg/kg给药：IP结果：化学诱导的大鼠纤维肉瘤肿瘤和自发性肿瘤消退,最有效浓度为556μg/kg。
参考文献	[1]. Bhuyan BK, et al. Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture. Cancer Res. 1981;41(1):18-24. [2]. Bhuyan BK, et al. Differential interaction of nogalamycin with DNA of varying base composition. Proc Natl Acad Sci U S A. 1965;54(2):566-572. [3]. Bempong MA. Cytological effect of nogalamycin in mammals and regression of methylcholanthrene-induced and spontaneous tumors in rats. Int J Clin Pharmacol Biopharm. 1976;14(1):6-14.

密度	1.49g/cm3
沸点	899.9ºC at 760mmHg
分子式	C₃₉H₄₉NO₁₆
分子量	787.80
闪点	498.1ºC
精确质量	787.30500
PSA	229.44000
LogP	1.13800
外观性状	固体
蒸汽压	7.49E-35mmHg at 25°C
折射率	1.648
储存条件	-20°C，密封，干燥

诺拉霉素毒性英文版

符号	GHS07, GHS08
信号词	Danger
危害声明	H302-H312-H332-H350-H360
警示性声明	P201-P280-P308 + P313
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	45-46-61-20/21/22
安全声明 (欧洲)	53-22-36/37/39-45
危险品运输编码	NONH for all modes of transport
RTECS号	RA4550000

Kinetic characterization of small DNA-binding molecules interacting with a DNA strand on a quartz crystal microbalance.

Anal. Biochem. 492 , 34-42, (2015)

Quantitative studies of the binding of various DNA-binding antibiotics with dsDNA are useful for drug design, not only for effective antibiotics, but also for antitumor drugs. We studied the binding k...

The intercalation of DNA double helices with doxorubicin and nogalamycin.

J. Mol. Graph. Model. 26(1) , 14-9, (2007)

A variety of molecules bind to DNA in its major and minor grooves, and some, like the anthraquinoids, are known to form intercalates in which these molecules are inserted directly into the double heli...

Engineering anthracycline biosynthesis toward angucyclines.

Antimicrob. Agents Chemother. 47(4) , 1291-6, (2003)

The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic bios...

antibiotic205t3

nogalomycin

NOGALAMYCIN

NOGALAMYCIN,STREPTOMYCES NOGALATER