制霉素

常用名 制霉素 英文名 Nystatin dihydrate
CAS号 1400-61-9 分子量 276.414
密度 0.9±0.1 g/cm3 沸点 400.2±14.0 °C at 760 mmHg
分子式 C47H75NO17 熔点 N/A
MSDS制霉素的MSDS|SDS|pdf下载 美版 闪点 297.0±15.2 °C
 制霉素作用
用途 菌谱及抗菌机理与两性霉素B相似,主要用于皮肤粘膜、口腔、阴道的白色念珠菌感染。
用途 主要用于皮肤粘膜、口腔、肠道和阴道的白色念珠菌感染,高浓度有杀菌作用

 制霉素物理化学性质

[ 密度 ]: 0.9±0.1 g/cm3
[ 沸点 ]: 400.2±14.0 °C at 760 mmHg
[ 分子式 ]: C47H75NO17
[ 分子量 ]: 276.414
[ 闪点 ]: 297.0±15.2 °C
[ 精确质量 ]: 276.208923
[ PSA ]: 327.45000
[ LogP ]: 6.14
[ 外观性状 ]: 黄色悬浮物
[ 蒸汽压 ]: 0.0±2.0 mmHg at 25°C
[ 折射率 ]: 1.504

 制霉素MSDS


Section 1. Chemical Product and Company Identification
Nystatin
Common Name/
Trade Name
Nystatin

Section 3. Hazards Identification
Potential Acute HealthSlightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Effects
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Not available.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if
irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious InhalationNot available.
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to
Ingestion
an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention
if symptoms appear.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsNot available.
Not available.
Flammable Limits
Not available.
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards inRisks of explosion of the product in presence of mechanical impact: Not available.
Presence of VariousRisks of explosion of the product in presence of static discharge: Not available.
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Material in powder form, capable of creating a dust explosion.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
dust explosion hazard.
Hazards
Nystatin

Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do
Precautions
not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or
the label. Keep away from incompatibles such as oxidizing agents.
StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C
(46.4°F). Refrigerate. Moisture sensitive. Sensitive t o light. Store in light-resistant containers.

Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels
below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powdered solid.)OdorOdor suggestive of cereal
Not available.
Taste
Not available.
Molecular Weight
ColorTan. Yellow. (Light.)
pH (1% soln/water)Not available.
Boiling PointNot available.
Melting PointDecomposition temperature: >160°C (320°F)
Not available.
Critical Temperature
Specific GravityNot available.
Not applicable.
Vapor Pressure
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Water/Oil Dist. Coeff.The product is more soluble in oil; log(oil/water) = 7.1
Not available.
Ionicity (in Water)
Dispersion PropertiesNot available.
Very slightly soluble in cold water.
Solubility
Insoluble in diethyl ether.
Solubility in Water: 360 mg/l at 24 C.
Nystatin

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability TemperatureNot available.
Excess heat, incompatible materials, light, moisture, dust generation.
Conditions of Instability
Incompatibility with various Reactive with oxidizing agents.
substances
Non-corrosive in presence of glass.
Corrosivity
Special Remarks onMoisture sensitive Sensitive to light.
ReactivityHeat, light and oxygen accelerate decomposition.
Special Remarks onNot available.
Corrosivity
Will not occur.
Polymerization

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsAcute oral toxicity (LD50): 8000 mg/kg [Mouse].
Chronic Effects on Humans Not available.
Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.
Chronic Effects on Humans May affect genetic material (mutagenic)
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, diarrhea, and stomach pain.
Chronic Potential Health Effects:
Ingestion: Prolonged or repeated ingestion may cause weight loss. It may also affect behavior, blood
(changes in serum composition), and urinary system (kidneys).
Inhalation: Prolonged or repeated inhalation may cause allergic reaction.
Skin: Prolonged or repeated skin contact may cause allergic contact dermatitis, although it is rare.

Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation
products may arise.
Toxicity of the ProductsThe product itself and its products of degradation are not toxic.
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation
Nystatin

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has
Proposition 65found to cause cancer which would require a warning under the statute: No products were found.
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
Other Regulations
No. 215-749-0).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
This product is not classifiedNot applicable.
DSCL (EEC)
according to the EU regulations.
Health Hazard
HMIS (U.S.A.)1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Nystatin
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 制霉素毒性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RF5950000
CHEMICAL NAME :
Nystatin
CAS REGISTRY NUMBER :
1400-61-9
LAST UPDATED :
199512
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C46-H83-N-O18
MOLECULAR WEIGHT :
938.30
WISWESSER LINE NOTATION :
T-38-VO D&V GU IU MU OU QU SUTJ C1 D1 EQ F1 WQ A&VQ B&Q F&Q G&Q J&Q L&Q N&Q UO- BT6OTJ CQ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24305 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
180 mg/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 33,306,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1053 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 8736 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1053 No. of Facilities: 372 (estimated) No. of Industries: 1 No. of Occupations: 10 No. of Employees: 25202 (estimated) No. of Female Employees: 22859 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9349 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2199 (estimated) No. of Female Employees: 2176 (estimated)

 制霉素安全信息

[ 个人防护装备 ]: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]: F, C
[ 风险声明 (欧洲) ]: R11
[ 安全声明 (欧洲) ]: S22-S24/25
[ 危险品运输编码 ]: NONH for all modes of transport
[ RTECS号 ]: RF5950000
[ 海关编码 ]: 2942000000

 制霉素海关

[ 海关编码 ]: 2942000000

 制霉素文献64

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