4-羟基-4-甲基-2-戊酮

常用名 4-羟基-4-甲基-2-戊酮 英文名 diacetone alcohol
CAS号 123-42-2 分子量 116.158
密度 0.9±0.1 g/cm3 沸点 168.1±0.0 °C at 760 mmHg
分子式 C6H12O2 熔点 -42.8 °C
MSDS4-羟基-4-甲基-2-戊酮的MSDS|SDS|pdf下载 中文版 美版 闪点 61.7±0.0 °C
符号 GHS02 GHS07
GHS02, GHS07
信号词 Warning
 用途
【用途一】
用作高沸点溶剂、喷漆稀释剂、木材着色剂、除锈剂及染料等的原料
【用途二】
用作染料的原料及树脂的溶液
【用途三】
二丙酮醇是由丙酮制造亚异丙基丙酮、甲基异丁基酮、甲基异丁基甲醇及己二醇、佛尔酮、异佛尔酮过程中的中间体二丙酮醇可用以制取金属清洁剂、木材防腐剂、照相软片和药物的防腐剂、抗冻剂、液压油溶剂、萃取剂和纤维整理剂等。二丙酮醇广泛用作静电喷漆、赛璐珞、硝化纤维、脂肪、油脂、蜡和树脂等的溶剂。
【用途四】
乙酸纤维素和酯化纤维素、赛璐珞等的溶剂。生化研究。电泳分析。木材防腐剂。
更多

 4-羟基-4-甲基-2-戊酮名称

[ 中文名 ]: 4-羟基-4-甲基-2-戊酮
[ 英文名 ]: diacetone alcohol
[中文别名 ]: 甲基戊酮醇
二丙酮醇
双丙酮醇
[英文别名 ]: 4-hydroxy-4-methylpentan-2-one
Diacetone Alcohol
4-Hydroxy-4-methyl-2-pentanone

 4-羟基-4-甲基-2-戊酮物理化学性质

[ 密度 ]: 0.9±0.1 g/cm3
[ 沸点 ]: 168.1±0.0 °C at 760 mmHg
[ 熔点 ]: -42.8 °C
[ 分子式 ]: C6H12O2
[ 分子量 ]: 116.158
[ 闪点 ]: 61.7±0.0 °C
[ 精确质量 ]: 116.083733
[ PSA ]: 37.30000
[ LogP ]: -0.09
[ 外观性状 ]: 透明无色液体
[ 蒸汽密度 ]: 4 (vs air)
[ 蒸汽压 ]: 0.5±0.6 mmHg at 25°C
[ 折射率 ]: 1.427
[ 储存条件 ]: 包装完整、轻装轻卸,库房通风、远离明火、高温、与氧化剂分开存放
[ 水溶解性 ]: MISCIBLE

 4-羟基-4-甲基-2-戊酮MSDS

第一部分:化学品名称
化学品中文名称: 双丙酮醇;4-羟基-4-甲基-2-戊酮
化学品英文名称: Diacetone alcohol;4-Hydroxy-4-methyl-2-pentanone
中文俗名或商品名:
Synonyms:
CAS No.: 123-42-2
分子式: C6H12O2
分子量: 116.16
第二部分:成分/组成信息
纯化学品混合物
化学品名称:双丙酮醇;4-羟基-4-甲基-2-戊酮
有害物成分 含量 CAS No.
双丙酮醇 123-42-2
第三部分:危险性概述
危险性类别: 第3.2类 中闪点易燃液体
侵入途径: 吸入 食入 经皮吸收
健康危害: 对眼、鼻、喉粘膜有刺激性。吸入高浓度中毒时可见粘膜刺激、胸闷,严重者可造成麻醉。由于血压下降可使肝肾受到损害,可因呼吸中枢抑制而死亡。长期反复接触可引起皮炎。
环境危害:
燃爆危险: 本品易燃,具刺激性。
第四部分:急救措施
皮肤接触: 脱去污染的衣着,用流动清水冲洗。
眼睛接触: 立即提起眼睑,用流动清水冲洗。
吸入: 迅速脱离现场至空气新鲜处。保持呼吸道通畅。呼吸困难时给输氧。呼吸停止时,立即进行人工呼吸。就医。
食入: 误服者给饮大量温水,催吐,就医。
第五部分:消防措施
危险特性: 其蒸气与空气形成爆炸性混合物,遇明火、高热能引起燃烧爆炸。与氧化剂能发生强烈反应,引起燃烧或爆炸。若遇高热,容器内压增大,有开裂和爆炸的危险。
有害燃烧产物: 一氧化碳、二氧化碳。
灭火方法及灭火剂: 泡沫、二氧化碳、干粉、砂土。用水灭火无效。
消防员的个体防护:
禁止使用的灭火剂:
闪点(℃): <23
自燃温度(℃): 603
爆炸下限[%(V/V)]: 1.8
爆炸上限[%(V/V)]: 6.9
最小点火能(mJ):
爆燃点:
爆速:
最大燃爆压力(MPa):
建规火险分级:
第六部分:泄漏应急处理
应急处理: 疏散泄漏污染区人员至安全压,禁止无关人员进入污染区,切断火源。建议应急处理人员戴自给式呼吸器,穿一般消防防护服。在确保安全情况下堵漏。喷水雾会减少蒸发,但不能降低泄漏物在受限制空间内的易燃性。用活性炭或其它惰性材料吸收,收集运至废物处理场所处置。也可以用大量水冲洗,经稀释的洗水放入废水系统。如大量泄漏,利用围堤收容,然后收集、转移、回收或无害处理后废弃。
第七部分:操作处置与储存
操作注意事项: 密闭操作,注意通风。操作人员必须经过专门培训,严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具(半面罩),戴化学安全防护眼镜,穿防静电工作服,戴橡胶手套。远离火种、热源,工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、还原剂、碱类接触。灌装时应控制流速,且有接地装置,防止静电积聚。搬运时要轻装轻卸,防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项: 储存于阴凉、通风的库房。远离火种、热源。库温不宜超过30℃。应与氧化剂、还原剂、碱类分开存放,切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
第八部分:接触控制/个体防护
最高容许浓度: 中国MAC:未制定标准苏联MAC:100mg/m3 美国TWA:OSHA 50ppm,238m
监测方法:
工程控制: 密闭操作,注意通风。
呼吸系统防护: 空气中浓度超标时,佩带防毒口罩。
眼睛防护: 戴安全防护眼镜。
身体防护: 穿相应的防护服。
手防护: 高浓度接触时,戴防护手套。
其他防护: 工作现场严禁吸烟。注意个人清洁卫生。避免长期反复接触。
第九部分:理化特性
外观与性状: 无色液体,有使人感觉愉快的气味。
pH:
熔点(℃): -44
沸点(℃): 164.4
相对密度(水=1): 0.94
相对蒸气密度(空气=1): 4.0
饱和蒸气压(kPa): 0.13/20℃
燃烧热(kJ/mol):
临界温度(℃):
临界压力(MPa):
辛醇/水分配系数的对数值:
闪点(℃): <23
引燃温度(℃): 603
爆炸上限%(V/V): 6.9
爆炸下限%(V/V): 1.8
分子式: C6H12O2
分子量: 116.16
蒸发速率:
粘性:
溶解性: 与水混溶,可混溶于乙醇、醚、芳烃。
主要用途: 用作溶剂,也用于制金属清洁剂、木材防腐剂、照相软片和药物的防腐剂、抗冻剂。
第十部分:稳定性和反应活性
稳定性: 在常温常压下 稳定
禁配物: 强氧化剂、强碱、强还原剂。
避免接触的条件:
聚合危害: 不能出现
分解产物: 一氧化碳、二氧化碳。
第十一部分:毒理学资料
急性毒性: 属低毒类 LD50:4000mg/kg(大鼠经口);13500mg/kg(兔经皮) LC50:
急性中毒:
慢性中毒:
亚急性和慢性毒性:
刺激性:
致敏性:
致突变性:
致畸性:
致癌性:
第十二部分:生态学资料
生态毒理毒性:
生物降解性:
非生物降解性:
生物富集或生物积累性:
第十三部分:废弃处置
废弃物性质:
废弃处置方法: 用焚烧法处置。
废弃注意事项:
第十四部分:运输信息
危险货物编号: 32077
UN编号: 1148
包装标志:
包装类别:
包装方法:
运输注意事项: 储存于阴凉、通风仓间内。远离火种、热源。仓温不宜超过30℃。防止阳光直射。保持容器密封。应与氧化剂、酸类分开存放。储存间内的照明、通风等设施应采用防爆型,开关设在仓外。配备相应品种和数量的消防器材,桶
RETCS号:
IMDG规则页码:
第十五部分:法规信息
国内化学品安全管理法规: 化学危险物品安全管理条例 (1987年2月17日国务院发布),化学危险物品安全管理条例实施细则 (化劳发[1992] 677号),工作场所安全使用化学品规定 ([1996]劳部发423号)等法规,针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定;常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第3.2 类中闪点易燃液体。
国际化学品安全管理法规:
第十六部分:其他信息
参考文献: 1.周国泰,化学危险品安全技术全书,化学工业出版社,1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编,化学品毒性法规环境数据手册,中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间: 年月日
填表部门:
数据审核单位:
修改说明:
其他信息: 1
MSDS修改日期: 年月日

 4-羟基-4-甲基-2-戊酮毒性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SA9100000
CHEMICAL NAME :
2-Pentanone, 4-hydroxy-4-methyl-
CAS REGISTRY NUMBER :
123-42-2
BEILSTEIN REFERENCE NO. :
1740440
LAST UPDATED :
199712
DATA ITEMS CITED :
44
MOLECULAR FORMULA :
C6-H12-O2
MOLECULAR WEIGHT :
116.18
WISWESSER LINE NOTATION :
QX1&1&1V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Human
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,262,1946
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
100 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - headache Gastrointestinal - nausea or vomiting
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
400 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1500 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/29/1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3024 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,669,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
933 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,3,1961
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4653 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,21,1974
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2792 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2792 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 33,175,1928 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4494 mg/m3/6W-I
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536235 *** REVIEWS *** ACGIH TLV-TWA 238 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 50 ppm (240 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,70,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (238 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (240 mg/m3);STEL 75 ppm (360 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-RUSSIA:STEL 100 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3);STEL 75 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIACETONE ALCOHOL-air:10H TWA 50 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4016 No. of Facilities: 20435 (estimated) No. of Industries: 191 No. of Occupations: 95 No. of Employees: 167915 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4016 No. of Facilities: 20857 (estimated) No. of Industries: 194 No. of Occupations: 116 No. of Employees: 264662 (estimated) No. of Female Employees: 67291 (estimated)

 4-羟基-4-甲基-2-戊酮安全信息

[ 符号 ]: GHS02 GHS07
GHS02, GHS07
[ 信号词 ]: Warning
[ 危害声明 ]: H226-H319
[ 警示性声明 ]: P305 + P351 + P338
[ 个人防护装备 ]: Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]: Xi:Irritant
[ 风险声明 (欧洲) ]: R36
[ 安全声明 (欧洲) ]: S24/25
[ 危险品运输编码 ]: UN 1148 3/PG 3
[ WGK德国 ]: 1
[ RTECS号 ]: SA9100000
[ 包装等级 ]: III
[ 危险类别 ]: 3
[ 海关编码 ]: 2914130000

 4-羟基-4-甲基-2-戊酮合成线路

~%

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 4-羟基-4-甲基-2-戊酮制备

【方法一】
由丙酮在碱性条件下经缩合而得。每吨产品消耗丙酮1250kg。

 4-羟基-4-甲基-2-戊酮海关

[ 海关编码 ]: 2914400090
[ 中文概述 ]: 2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
[申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装
[ Summary ]: 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 4-羟基-4-甲基-2-戊酮文献8

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