923289-20-7

• 常用中文名：N-(6-乙酰基-3-甲氧基-2-甲基苯基)-4-异丙基噻唑-2-甲酰胺
• 常用英文名：N-(6-ACETYL-3-METHOXY-2-METHYLPHENYL)-4-(1-METHYLETHYL)-2-THIAZOLECARBOXAMIDE
• CAS号：923289-20-7
• 分子式：C₁₇H₂₀N₂O₃S
• 分子量：332.41700
• 发布时间：2018-06-11 21:10:27
• 更新时间：2024-01-09 17:03:30

名称

• 中文名: N-[6-乙酰基-2-甲基-3-(甲基氧基)苯基]-4-(1-甲基乙基)-1,3-噻唑-2-羧酰胺
• 英文名: N-(6-acetyl-3-methoxy-2-methylphenyl)-4-propan-2-yl-1,3-thiazole-2-carboxamide
• 英文别名: 2-Thiazolecarboxamide,N-(6-acetyl-3-methoxy-2-methylphenyl)-4-(1-methylethyl); THI053; N-(6-acetyl-3-methoxy-2-methylphenyl)-4-isopropylthiazole-2-carboxamide; N-[6-acetyl-2-methyl-3-(methyloxy)phenyl]-4-(1-methylethyl)-1,3-thiazole-2-carboxamide; N-(6-acetyl-2-methyl-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide; N-(6-acetyl-3-methoxy-2-methylphenyl)-4-(1-methylethyl)-2-Thiazolecarboxamide; 2'-(4-isopropylthiazol-2-ylcarbonylamino)-4'-methoxy-3'-methylacetophenone; 1-acetyl-2-[(4-isopropyl-thiazol-2-yl)-carbonylamino]-3-methyl-4-methoxy-benzene; 2'-[[(4-iso-propylthiazole-2-yl)(oxo)methyl]amino]-4'-methoxy-3'-methylacetophenone

物化性质

• 分子式: C₁₇H₂₀N₂O₃S
• 分子量: 332.41700
• 精确质量: 332.11900
• PSA: 100.02000
• LogP: 4.42240
• 储存条件: 2-8°C

合成路线

923289-59-2 912347-94-5 ~89% 923289-20-7

文献：TIBOTEC PHARMACEUTICALS LTD. Patent: WO2008/92954 A2, 2008 ; Location in patent: Page/Page column 29 ;

912347-94-5 1108658-73-6 ~41% 923289-20-7

文献：Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3021 - 3026

79-37-8 300831-06-5 912347-94-5 ~93% 923289-20-7

文献：InterMune, Inc. Patent: US2009/269305 A1, 2009 ;

300831-06-5 912347-94-5 ~% 923289-20-7

文献：Raboisson, Pierre; Lin, Tse-I; Kock, Herman de; Vendeville, Sandrine; Vreken, Wim Van de; McGowan, David; Tahri, Abdellah; Hu, Lili; Lenz, Oliver; Delouvroy, Frederic; Surleraux, Dominique; Wigerinck, Piet; Nilsson, Magnus; Rosenquist, Asa; Samuelsson, Bertil; Simmen, Kenneth Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5095 - 5100

563-80-4 ~% 923289-20-7

文献：Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3021 - 3026

19967-55-6 ~% 923289-20-7

文献：Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3021 - 3026

19500-02-8 ~% 923289-20-7

文献：Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3021 - 3026

上下游产品

上游产品  8
923289-59-2 912347-94-5 1108658-73-6 79-37-8
300831-06-5 563-80-4 19967-55-6 19500-02-8
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