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| 中文名 | L-亮氨酸-7-酰氨基-4-甲基香豆素盐酸盐 |
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| 英文名 | L-Leucine-(4-methyl-7-coumarinylamide) hydrochloride |
| 中文别名 |
1,2-二软酯酰基蛋黄素
L-亮氨酰7-氨基-4-甲基香豆素盐酸盐 |
| 英文别名 |
MFCD00043262
2-amino-4-methyl-N-(4-methyl-2-oxochromen-7-yl)pentanamide,hydrochloride H-Leu-AMC.HCL |
| 描述 | L-亮氨酸-7-氨基-4-甲基香豆素(Leu-AMC)盐酸盐是LAP3(亮氨酸氨基肽酶)的亮蓝色荧光肽基底物。L-亮氨酸-7-氨基-4-甲基香豆素盐酸盐可用于体外亮氨酸氨基肽酶抑制试验[1]。 |
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| 相关类别 | |
| 体外研究 | 在KB 3.1细胞的亮氨酸氨基肽酶抑制试验中。观察到化合物3和5弱抑制金黄色葡萄球菌的生物膜形成,并抑制KB 3.1细胞中ʟ-Leu AMC水解的抑制活性[1]。水解7-氨基-4-甲基香豆素(AMC)的量在荧光分光光度计中测定(激发/发射：365/440 nm)[1]。 |
| 参考文献 |
| 沸点 | 503ºC at 760 mmHg |
|---|---|
| 熔点 | 248ºC |
| 分子式 | C16H21ClN2O3 |
| 分子量 | 324.80300 |
| 闪点 | 258ºC |
| 精确质量 | 324.12400 |
| PSA | 85.33000 |
| LogP | 3.98860 |
| 外观性状 | 白色至近乎于白色粉末 |
| 储存条件 | 存放在密封容器内，并放在阴凉，干燥处。 |
| 稳定性 | 指定条件下稳定，远离氧化物，强酸，强碱。 |
| 分子结构 | 1、 摩尔折射率：80.72 2、 摩尔体积（m3/mol）：238.6 3、 等张比容（90.2K）：639.7 4、 表面张力（dyne/cm）：51.6 5、 极化率（10-24cm3）：32.00 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:3 3.氢键受体数量:4 4.可旋转化学键数量:4 5.互变异构体数量:43 6.拓扑分子极性表面积81.4 7.重原子数量:22 8.表面电荷:0 9.复杂度:445 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
| 更多 | 1. 性状：白色或者类白色粉末。 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：248 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定 。 |
Synonym:None known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 62480-44-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: almost white Odor: none reported pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 248 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: > 248 deg C Solubility in water: Specific Gravity/Density: Molecular Formula: C16H20N2O3.HCl Molecular Weight: 288.1516 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, dust generation, excess heat. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 62480-44-8 unlisted. LD50/LC50: Not available. Carcinogenicity: L-Leucine-(4-Methyl-7-Coumarinylamide) Hydrochloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 62480-44-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 62480-44-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 62480-44-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
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生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境。
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| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 安全声明 (欧洲) | S22-S24/25 |
| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2932209090 |
| 上游产品 0 | |
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| 下游产品 1 | |
| 海关编码 | 2932209090 |
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| 中文概述 | 2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
