7619-53-6

• 常用中文名：{2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸
• 常用英文名：Zuclomiphene (citrete)
• CAS号：7619-53-6
• 分子式：C₃₂H₃₆ClNO₈
• 分子量：598.08300
• 相关类别： 研究领域 内分泌
• 发布时间：2018-12-27 19:49:29
• 更新时间：2024-02-04 16:05:48
• Zuclomiphene citrate 是柠檬酸克罗米芬的顺式异构体。Zuclomiphene citrate 具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素 (LH) 的分泌。Zuclomiphene citrate 也是一种口服活性降胆固醇药。

名称

• 中文名: {2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸
• 英文名: Clomiphene citrate, cis
• 英文别名: cis-6,cis-11-Methyl-octadecadienoat; cis-clomiphene citrate; clomphencitrate; cis-cis-6,11-Octadecadiensaeuremethylester; Methyl-cis,cis-octadeca-6,11-dienoat; cis,cis-Octadeca-6,11-diensaeure-methylester; clomifen citrate; I-Dihydrocitrat; zuclomiphene citrate

物化性质

• 分子式: C₃₂H₃₆ClNO₈
• 分子量: 598.08300
• 精确质量: 597.21300
• PSA: 144.60000
• LogP: 5.31410
• 外观性状: 固体
• 储存条件: 2-8°C

生物活性

• 描述: Zuclomiphene citrate 是柠檬酸克罗米芬的顺式异构体。Zuclomiphene citrate 具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素 (LH) 的分泌。Zuclomiphene citrate 也是一种口服活性降胆固醇药。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 内分泌
  研究领域 >> 代谢疾病
• 靶点:

  Estrogen Receptor/ERR

• 参考文献:

  [1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50.

  [2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6.

  [3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8.

  [4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YE0930000 CAS REGISTRY NUMBER : 7619-53-6 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C26-H28-Cl-N-O.C6-H8-O7 MOLECULAR WEIGHT : 598.14 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 30 mg/kg SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,23,1973