204589-80-0

• 常用中文名：(3R,4S)-1-(4-氟苯基)-2-氧代-4-[4-(苄氧基)苯基]-3-氮杂环丁烷丙酸甲酯
• 常用英文名：Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate
• CAS号：204589-80-0
• 分子式：C₂₆H₂₄FNO₄
• 分子量：433.471
• 发布时间：2018-12-29 21:41:35
• 更新时间：2024-01-02 19:57:51

名称

• 中文名: (3R,4S)-1-(4-氟苯基)-2-氧代-4-[4-(苄氧基)苯基]-3-氮杂环丁烷丙酸甲酯
• 英文名: methyl 3-[(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-phenylmethoxyphenyl)azetidin-3-yl]propanoate
• 中文别名: 依替米贝--丙酸甲酯; 依替米贝中间体F; 依折麦布中间体4; 3-(3-［2-氧代-4-(卞氧苯基)-1-(4-氟苯基)-氮杂环丁烷基])丙酸甲酯
• 英文别名: Methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxo-3-azetidinyl]propanoate; Methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate; methyl 3-{(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl}propionate; Methyl 3-((2S,3R)-2-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)propanoate; 3-Azetidinepropanoic acid, 1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-, methyl ester, (3R,4S)-; (3R,4S)-1-(4-fluorophenyl)-3-[3-(methoxy)-3-oxopropyl]-4-(4-benzyloxyphenyl)-2-azetidinone; Ezetimibe Intermediate-H

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 628.3±55.0 °C at 760 mmHg
• 分子式: C₂₆H₂₄FNO₄
• 分子量: 433.471
• 闪点: 333.8±31.5 °C
• 精确质量: 433.168945
• PSA: 55.84000
• LogP: 4.60
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.589

合成路线

917392-16-6 ~74% 204589-80-0

文献：Uppala, Venkata Bhaskara Rao; Vaddadi, Pattabhi Ramayya; Sunkara, Vishnu Vardhan; Cheemalapati, Venkata Annapurna Sasikala; Padaga, Kanaka Seshu Kumar Patent: US2007/49748 A1, 2007 ; Location in patent: Page/Page column 9 ;

934245-17-7 ~76% 204589-80-0

文献：Sasikala; Padi, Pratap Reddy; Sunkara, Vishnuvardhan; Ramayya, Pattabhi; Dubey; Uppala, Venkata Bhaskar Rao; Praveen, Cherukupally Organic Process Research and Development, 2009 , vol. 13, # 5 p. 907 - 910

917392-16-6 ~% 99395-88-7 204589-80-0

文献：WO2006/137080 A1, ; Page/Page column 12 ;